(2R,3R)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

Base Information

Chemical Name:(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde
CAS No.:74741-36-9
Molecular Formula:C₁₇H₁₆O₆
Molecular Weight:316.31
Hs Code.:

Synonyms:(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

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Technology Process of (2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

There total 14 articles about (2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 98314-84-2,103627-56-1
3-(4-benzyloxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-carbaldehyde

: 74741-36-9
(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; Ambient temperature;
DOI:10.1248/cpb.33.1419

Reference yield:

: 65298-98-8
4-hydroxy-3-(methoxymethoxy)benzaldehyde

: 74741-36-9
(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; ammonium chloride; palladium on activated charcoal; In methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1419

Reference yield:

: 7572-90-9
ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate

: 74741-36-9
(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; ammonium chloride; palladium on activated charcoal; In methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1419