(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Base Information

Chemical Name:(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone
CAS No.:98314-87-5
Molecular Formula:C₃₃H₃₈O₁₃
Molecular Weight:642.657
Hs Code.:

Synonyms:(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Suppliers and Price of (E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

There total 8 articles about (E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 36804-11-2
2,4,6-tri-MOM phloracetophenone

: 98314-86-4
(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

: 98314-87-5
(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Guidance literature:: With sodium hydroxide; In ethanol; for 8h;
DOI:10.1248/cpb.33.1419

Reference yield:

: 65298-98-8
4-hydroxy-3-(methoxymethoxy)benzaldehyde

: 98314-87-5
(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

7: 94 percent / NaOH / ethanol / 8 h

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419

Reference yield:

: 7572-90-9
ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate

: 98314-87-5
(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

7: 94 percent / NaOH / ethanol / 8 h

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;
DOI:10.1248/cpb.33.1419