(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

Base Information

• Chemical Name: (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde
• CAS No.: 98314-86-4
• Molecular Formula: C₁₉H₂₀O₇
• Molecular Weight: 360.364

Synonyms:(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

Chemical Property of (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

There total 7 articles about (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

chloromethyl methyl ether (107-30-2) + (2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde (74741-36-9) → (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (98314-86-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; paraffin; for 2h; Ambient temperature;

DOI:10.1248/cpb.33.1419

Reference yield:

4-hydroxy-3-(methoxymethoxy)benzaldehyde (65298-98-8) → (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (98314-86-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1248/cpb.33.1419

Reference yield:

ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate (7572-90-9) → (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (98314-86-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 66 percent / tert-BuOK / dimethylformamide / 3 h / Ambient temperature

2: 94 percent / NH₄Cl / methanol / 1 h / Heating

3: 97 percent / NaBH₄ / ethanol / 8 h / Ambient temperature

4: 70 percent / sulfuric acid (5percent) / acetic acid / 0.5 h / 70 °C

5: 63 percent / H₂ / Pd-C (5percent) / ethyl acetate; ethanol / Ambient temperature

6: 79 percent / NaH / tetrahydrofuran; paraffin / 2 h / Ambient temperature

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; ammonium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; paraffin;

DOI:10.1248/cpb.33.1419

upstream raw materials:

chloromethyl methyl ether

(2R*,3R*)-3-(4-Hydroxy-3-methoxyphenyl)-2-hydroxymethyl-1,4-benzodioxan-6-aldehyde

4-hydroxy-3-(methoxymethoxy)benzaldehyde

ethyl 2-bromo-3-(4-benzyloxy-3-methoxyphenyl)-3-oxopropionate

Downstream raw materials:

(E)-3-[(2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone

(+/-)-silybin

{3-[(2R,3R)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-oxiranyl}-(2,4,6-tris-methoxymethoxy-phenyl)-methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 98314-86-4 (2S,3S)-2-Hydroxymethyl-3-(3-methoxy-4-methoxymethoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send