1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene

Base Information

• Chemical Name: 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene
• CAS No.: 528869-08-1
• Molecular Formula: C₁₂H₁₂F₄O₂
• Molecular Weight: 264.22
• Mol file: 528869-08-1.mol

Synonyms:1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene

Chemical Property of 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene

There total 1 articles about 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetrafluorobenzaldehyde (19842-76-3) + 2,2-dimethoxy-propane (77-76-9) → 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene (528869-08-1) + 1,2,4,5-tetrafluoro-3-bis(3-hydroxy-2,2-dimethylpropyloxy)methylbenzene

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 72h; Heating;

DOI:10.1016/S0022-1139(02)00289-0

Reference yield: 73.0%

formic acid ethyl ester (109-94-4) + 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene (528869-08-1) → 1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)-6-formylbenzene (528869-14-9)

Guidance literature:

1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene; With n-butyllithium; In tetrahydrofuran; at -60 ℃; for 0.25h;

formic acid ethyl ester; In tetrahydrofuran; at -60 - 20 ℃;

DOI:10.1016/S0022-1139(02)00289-0

Reference yield:

1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)benzene (528869-08-1) → 2,3,5,6-tetrafluoroterephthalaldehyde (3217-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.25 h / -60 °C

1.2: 73 percent / tetrahydrofuran / -60 - 20 °C

2.1: 43 percent / aq. TFA / 2 h / Heating

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1016/S0022-1139(02)00289-0

upstream raw materials:

2,3,5,6-tetrafluorobenzaldehyde

2,2-dimethoxy-propane

Downstream raw materials:

1,2,4,5-tetrafluoro-3-(5,5-dimethyl-1,3-dioxan-2-yl)-6-formylbenzene

α,α’-dibromo-m-tetrafluoroxylene

2,3,5,6-tetrafluoro-1,4-benzenedimethanol

2,3,5,6-tetrafluoroterephthalaldehyde