4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Base Information

Chemical Name:4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine
CAS No.:103660-47-5
Molecular Formula:C15H19 N3 O
Molecular Weight:257.33
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50363359
Wikidata:Q82147025
ChEMBL ID:CHEMBL331938
Mol file:103660-47-5.mol

Synonyms:103660-47-5;4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine;Methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenyl ether;4-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]piperidine;4-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]piperidine;methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]phenyl ether;Bionet2_000729;Oprea1_581106;MLS001165224;CHEMBL331938;DTXSID50363359;HMS1366B03;HMS2878J05;MFCD00665098;AKOS005071286;SMR000549719;CS-0366383;FT-0680648;8L-707;J-513575;Methyl4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenylether

Suppliers and Price of 4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenyl ether >95%
1g
$ 603.00

Matrix Scientific
Methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenyl ether >95%
500mg
$ 486.00

Crysdot
4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine 95+%
1g
$ 455.00

Chemenu
Methyl4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenylether 95%
1g
$ 430.00

Apolloscientific
4-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]piperidine
1g
$ 540.00

American Custom Chemicals Corporation
METHYL 4-[3-(4-PIPERIDINYL)-1H-PYRAZOL-5-YL]-PHENYL ETHER 95.00%
5MG
$ 504.36

Total 16 raw suppliers

Chemical Property of 4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Chemical Property:

Melting Point:181-183°
PSA：49.94000
LogP:2.88110
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:257.152812238
Heavy Atom Count:19
Complexity:273

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-[3-(4-piperidinyl)-1H-pyrazol-5-yl]-phenyl ether >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NNC(=C2)C3CCNCC3

Technology Process of 4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine

There total 6 articles about 4-(5-(4-Methoxyphenyl)-1H-pyrazol-3-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78961-42-9
trans-2-(4-Methoxybenzylidene)-3-oxoquinuclidine

: 103660-47-5
4-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: With potassium hydroxide; hydrazine hydrate; In ethylene glycol; at 165 - 170 ℃; for 7h;
DOI:10.1007/BF00515032

Reference yield:

: 1025768-98-2
4-[5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 103660-47-5
4-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm030394f

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 103660-47-5
4-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 96 percent / 1,1'-carbonylbis-1H-imidazole / tetrahydrofuran / 12 h / 20 °C

2.1: hydrazine hydrate / ethanol / 12 h / Heating

3.1: CF₃CO₂H / CH₂Cl₂ / 4 h / 20 °C

With hydrazine hydrate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030394f