2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]-MALONIC ACID DIETHYL ESTER

Base Information

• Chemical Name: 2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]-MALONIC ACID DIETHYL ESTER
• CAS No.: 103506-04-3
• Molecular Formula: C₂₁H₂₀N₂O₁₀
• Molecular Weight: 460.397
• Mol file: 103506-04-3.mol

Synonyms:Malonicacid, [4-(p-methoxyphenoxy)-3,5-dinitrobenzylidene]-, diethyl ester (6CI)

Chemical Property of 2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]-MALONIC ACID DIETHYL ESTER

Chemical Property:

• PSA: 162.70000
• LogP: 4.85990

Purity/Quality:

97% ^*data from raw suppliers

2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]MALONIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]-MALONIC ACID DIETHYL ESTER

There total 4 articles about 2-[4-(4-METHOXY-PHENOXY)-3,5-DINITRO-BENZYLIDENE]-MALONIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-hydroxybenzylidene)malonic acid diethyl ester (17315-86-5) → [4-(4-methoxy-phenoxy)-3,5-dinitro-benzylidene]-malonic acid diethyl ester (103506-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / -5 °C / anschliessend mit konz. wss. HNO₃ bei -15grad behandeln

2: methanesulfonyl chloride; pyridine / Reaktion ueber 2 Stufen

With pyridine; sulfuric acid; methanesulfonyl chloride;

DOI:10.1021/jo01363a010

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → [4-(4-methoxy-phenoxy)-3,5-dinitro-benzylidene]-malonic acid diethyl ester (103506-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; piperidine; benzene

2: H₂SO₄ / -5 °C / anschliessend mit konz. wss. HNO₃ bei -15grad behandeln

3: methanesulfonyl chloride; pyridine / Reaktion ueber 2 Stufen

With piperidine; pyridine; sulfuric acid; acetic acid; methanesulfonyl chloride; benzene;

DOI:10.1021/jo01363a010

Reference yield:

diethyl malonate (105-53-3) → [4-(4-methoxy-phenoxy)-3,5-dinitro-benzylidene]-malonic acid diethyl ester (103506-04-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; piperidine; benzene

2: H₂SO₄ / -5 °C / anschliessend mit konz. wss. HNO₃ bei -15grad behandeln

3: methanesulfonyl chloride; pyridine / Reaktion ueber 2 Stufen

With piperidine; pyridine; sulfuric acid; acetic acid; methanesulfonyl chloride; benzene;

DOI:10.1021/jo01363a010

upstream raw materials:

(4-hydroxy-3,5-dinitro-benzylidene)-malonic acid diethyl ester

4-methoxy-phenol

2-(4-hydroxybenzylidene)malonic acid diethyl ester

4-hydroxy-benzaldehyde

Downstream raw materials:

[3,5-diiodo-4-(4-methoxy-phenoxy)-benzyl]-malonic acid diethyl ester

3-[4-(4-hydroxy-phenoxy)-3,5-diiodo-phenyl]-propionic acid

[3,5-diamino-4-(4-methoxy-phenoxy)-benzyl]-malonic acid diethyl ester