5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

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Chemical Name:5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole
CAS No.:215245-08-2
Molecular Formula:C₄₅H₅₄N₂O₇
Molecular Weight:734.933
Hs Code.:

Synonyms:5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

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Chemical Property of 5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

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Technology Process of 5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

There total 16 articles about 5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 215245-06-0
2-(4-{3-[2-(3-Bromo-propyl)-phenoxy]-propyl}-phenoxy)-tetrahydro-pyran

: 215244-99-8
3-(3-Methyl-butoxy)-5-{2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-ethoxy}-phenol

: 215245-08-2
5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 2h; from 0 deg C to RT;
DOI:10.1016/S0040-4039(98)01657-8

Reference yield:

: 61440-45-7
3-[4-(benzyloxy)phenyl]propan-1-ol

: 215245-08-2
5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / CBr₄, PPh₃ / tetrahydrofuran / 15 h / from 0 deg C to RT

2: 82 percent / NaH / dimethylformamide / 2 h / from 0 deg C to RT

3: 91 percent / CBr₄, PPh₃ / tetrahydrofuran / 15 h / from 0 deg C to RT

4: 82 percent / H₂ / Pd-C / ethyl acetate / 3.5 h / Ambient temperature

5: 86 percent / PPTS / CH₂Cl₂ / 1 h / from 0 deg C to RT

6: 78 percent / NaH / dimethylformamide / 2 h / from 0 deg C to RT

With carbon tetrabromide; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01657-8

Reference yield:

: 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol

: 215245-08-2
5-Methyl-3-[4-(2-{3-(3-methyl-butoxy)-5-[3-(2-{3-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-propoxy}-phenyl)-propoxy]-phenoxy}-ethyl)-phenyl]-[1,2,4]oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / NaH / dimethylformamide / 3 h / from 0 deg C to RT

2: 93 percent / CBr₄, PPh₃ / tetrahydrofuran / 15 h / from 0 deg C to RT

3: 82 percent / NaH / dimethylformamide / 2 h / from 0 deg C to RT

4: 91 percent / CBr₄, PPh₃ / tetrahydrofuran / 15 h / from 0 deg C to RT

5: 82 percent / H₂ / Pd-C / ethyl acetate / 3.5 h / Ambient temperature

6: 86 percent / PPTS / CH₂Cl₂ / 1 h / from 0 deg C to RT

7: 78 percent / NaH / dimethylformamide / 2 h / from 0 deg C to RT

With carbon tetrabromide; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01657-8