(4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER

Base Information

• Chemical Name: (4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER
• CAS No.: 103384-72-1
• Molecular Formula: C17H19 O4 P
• Molecular Weight: 318.309
• Mol file: 103384-72-1.mol

Synonyms:Phosphonicacid, (4-benzoylphenyl)-, diethyl ester (9CI)

Chemical Property of (4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER

Chemical Property:

• PSA: 62.41000
• LogP: 3.80900

Purity/Quality:

98%min ^*data from raw suppliers

(4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER

There total 3 articles about (4-BENZOYL-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-benzoylphenyl methane sulfonate (83887-62-1) + phosphonic acid diethyl ester (762-04-9) → diethyl (4-benzoylphenyl)phosphonate (103384-72-1)

Guidance literature:

With 2-[2-(dicyclohexylphosphino)-phenyl]-1-methyl-1H-indole; palladium diacetate; N-ethyl-N,N-diisopropylamine; In ethanol; tert-butyl alcohol; at 110 ℃; for 18h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03104

Reference yield: 10.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) + sodium diethyl phosphite (2303-76-6,118080-94-7) → benzophenone (119-61-9) + 4-Methylbenzophenone (134-84-9) + diethyl (4-benzoylphenyl)phosphonate (103384-72-1)

Guidance literature:

With dibenzo-18-crown-6; In dimethyl sulfoxide; electrolysis;

DOI:10.1021/jo00370a003

Reference yield:

phenyl(4-((tetrafluoro-λ5-boranyl)diazenyl)phenyl)methanone + phosphonic acid diethyl ester (762-04-9) → diethyl (4-benzoylphenyl)phosphonate (103384-72-1)

Guidance literature:

With 3-Chloropyridine; (triphenylphosphine)gold(I) chloride; In acetonitrile; at 50 ℃; for 5h;

DOI:10.1039/c6sc01742h

upstream raw materials:

(4-bromophenyl)(phenyl)methanone

sodium diethyl phosphite

4-benzoylphenyl methane sulfonate

phosphonic acid diethyl ester

Refernces

• 1、 Fu, Wai Chung,So, Chau Ming,Kwong, Fuk Yee. "Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates". supporting information. p. 5906 - 5909. Retrieved 2015/12/11.