(S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid

Base Information

• Chemical Name: (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid
• CAS No.: 137589-09-4
• Molecular Formula: C₁₃H₁₄F₃NO₄
• Molecular Weight: 305.254
• Mol file: 137589-09-4.mol

Synonyms:(S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid

Chemical Property of (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid

There total 3 articles about (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid (137589-08-3) → (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid (137589-09-4)

Guidance literature:

With sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

N-trifluoroacetyl-L-aspartic acid anhydride (777-33-3) → (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid (137589-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂; nitromethane / 1.) from 0 to 5 deg C, 1 h, 2.) RT, 2 d

2: 65 percent / H₂, H₂SO₄ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With aluminium trichloride; sulfuric acid; hydrogen; palladium on activated charcoal; In nitromethane; ethanol; dichloromethane;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

methoxybenzene (100-66-3) → (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid (137589-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂; nitromethane / 1.) from 0 to 5 deg C, 1 h, 2.) RT, 2 d

2: 65 percent / H₂, H₂SO₄ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With aluminium trichloride; sulfuric acid; hydrogen; palladium on activated charcoal; In nitromethane; ethanol; dichloromethane;

DOI:10.1016/0223-5234(94)90095-7

upstream raw materials:

(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid

N-trifluoroacetyl-L-aspartic acid anhydride

methoxybenzene

Refernces