(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid

Base Information

• Chemical Name: (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid
• CAS No.: 137589-08-3
• Molecular Formula: C₁₃H₁₂F₃NO₅
• Molecular Weight: 319.237
• Mol file: 137589-08-3.mol

Synonyms:(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid

Chemical Property of (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid

There total 1 articles about (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-trifluoroacetyl-L-aspartic acid anhydride (777-33-3) + methoxybenzene (100-66-3) → (S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid (137589-08-3)

Guidance literature:

With aluminium trichloride; In nitromethane; dichloromethane; 1.) from 0 to 5 deg C, 1 h, 2.) RT, 2 d;

DOI:10.1016/0223-5234(94)90095-7

Reference yield: 65.0%

(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid (137589-08-3) → (S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid (137589-09-4)

Guidance literature:

With sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

(S)-4-(4-methoxyphenyl)-4-oxo-2-trifluoroacetylaminobutanoic acid (137589-08-3) → (S)-4-(4-Methoxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-butyryl chloride

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂, H₂SO₄ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

2: PCl₅ / 1,2-dichloro-ethane / 2 h / 0 - 5 °C

With phosphorus pentachloride; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;

DOI:10.1016/0223-5234(94)90095-7

upstream raw materials:

N-trifluoroacetyl-L-aspartic acid anhydride

methoxybenzene

Downstream raw materials:

(S)-(+)-4-(4-methoxyphenyl)-2-trifluoroacetylaminobutanoic acid