[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

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Chemical Name:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone
CAS No.:1574110-33-0
Molecular Formula:C₂₃H₂₀ClF₃N₂O₂
Molecular Weight:448.872
Hs Code.:

Synonyms:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

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Chemical Property of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

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Technology Process of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

There total 6 articles about [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 45347-82-8
azetidine-3-ol

: 1574117-18-2
1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid

: 1574110-33-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; at 60 ℃;

Reference yield:

: 1574117-15-9
1-benzyl-3-(4-chlorophenyl)-4-methyl-1H-pyrrole-2-carboxylic acid

: 1574110-33-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.03 h

1.2: 1 h / 20 °C / Cooling

2.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / 1,2-dimethoxyethane / 60 °C

With ferrous(II) sulfate heptahydrate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dimethyl sulfoxide;

Reference yield:

: 37629-52-0
(E)-1-(4-chlorophenyl)-2-nitropropene

: 1574110-33-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(3-hydroxy-azetidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,5,7-triazabicyclo-[4,4,0]-dec-5-ene(TBD) polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

2.2: 20 °C

3.1: lithium hydroxide monohydrate; ethanol; water / tetrahydrofuran / 2 h / Reflux

4.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.03 h

4.2: 1 h / 20 °C / Cooling

5.1: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / 1,2-dimethoxyethane / 60 °C

With ferrous(II) sulfate heptahydrate; lithium hydroxide monohydrate; ethanol; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;