1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Base Information

Chemical Name:1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide
CAS No.:1429896-46-7
Molecular Formula:C₂₃H₂₄N₂O₂
Molecular Weight:360.456
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Suppliers and Price of 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

There total 5 articles about 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1429896-60-5
1-methyl-N-(quinolin-8-yl)cyclopentane-1-carboxamide

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 1429896-46-7
1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Guidance literature:: 1-methyl-N-(quinolin-8-yl)cyclopentane-1-carboxamide; 4-methoxyphenyl magnesium bromide; With N,N,N,N,-tetramethylethylenediamine; zinc dibromide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With iron(III)-acetylacetonate; 1,2-dichloro-2-methylpropane; o-phenylenebis(diphenylphosphine); In tetrahydrofuran; at 20 - 50 ℃; for 36h;
DOI:10.1021/ja402806f

Reference yield:

: 5453-85-0
ethyl cyclopentanecarboxylate

: 1429896-46-7
1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 10 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 60 °C

2.2: pH 2

3.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.2: 36 h / 20 - 50 °C

With n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc dibromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja402806f

Reference yield:

: 6553-72-6
ethyl 1-methyl-1-cyclopentanecarboxylate

: 1429896-46-7
1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 60 °C

1.2: pH 2

2.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: N,N,N,N,-tetramethylethylenediamine; zinc dibromide / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

4.2: 36 h / 20 - 50 °C

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; triethylamine; sodium hydroxide; zinc dibromide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja402806f