Nicotinamide, N,6-dimethyl- (6CI)

Base Information

• Chemical Name: Nicotinamide, N,6-dimethyl- (6CI)
• CAS No.: 102871-59-0
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol file: 102871-59-0.mol

Synonyms:Nicotinamide,N,6-dimethyl- (6CI)

Chemical Property of Nicotinamide, N,6-dimethyl- (6CI)

Chemical Property:

• PSA: 41.99000
• LogP: 1.14050

Purity/Quality:

N,6-dimethyl-3-Pyridinecarboxamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nicotinamide, N,6-dimethyl- (6CI)

There total 1 articles about Nicotinamide, N,6-dimethyl- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 6-methylnicotinate (21684-59-3) + methylamine (74-89-5) → 6-methyl-nicotinic acid methylamide (102871-59-0)

Guidance literature:

With water;

DOI:10.1021/jo01091a005

Reference yield:

6-methyl-nicotinic acid methylamide (102871-59-0) + phenylpropynoic acid methyl ester (4891-38-7) → N-methyl-6-(2-oxo-4-phenyl-but-3-ynyl)-nicotinamide

Guidance literature:

6-methyl-nicotinic acid methylamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

phenylpropynoic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2006.05.089

Reference yield:

6-methyl-nicotinic acid methylamide (102871-59-0) → 8-oxo-6-phenyl-8H-quinolizine-3-carboxylic acid methylamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 20 °C

2.1: acetonitrile / Heating

With lithium diisopropyl amide; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tetlet.2006.05.089

upstream raw materials:

ethyl 6-methylnicotinate

methylamine