5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

Base Information

Chemical Name:5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine
CAS No.:131853-52-6
Molecular Formula:C₂₄H₂₇ClN₄O₂
Molecular Weight:438.957
Hs Code.:

Synonyms:5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

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Chemical Property of 5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

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Technology Process of 5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

There total 7 articles about 5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5413-85-4
5-amino-4,6-dichloropyridimine

: 131853-48-0
1-amino-3,3-bis(benzyloxymethyl)cyclobutane

: 131853-52-6
5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

Guidance literature:: With triethylamine; In ethanol; for 48h; Heating;
DOI:10.1002/jhet.5570270655

Reference yield:

: 100-39-0
benzyl bromide

: 131853-52-6
5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH 2.) tetrabutylammonium hydrogen sulfate / 1.) THF, 2 h, r.t. 2.) THF, 18 h, r.t.

2: 100 percent / 98percent formic acid / Ambient temperature

3: 50 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.25 h / Ambient temperature

4: 46 percent / LiAlH / diethyl ether / 4 h / Heating

5: 74 percent / triethylamine / ethanol / 48 h / Heating

With pyridine; formic acid; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; In diethyl ether; ethanol;
DOI:10.1002/jhet.5570270655

Reference yield:

: 130369-33-4
(1-hydroxymethyl-3,3-dimethoxycyclobutyl)methanol

: 131853-52-6
5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH 2.) tetrabutylammonium hydrogen sulfate / 1.) THF, 2 h, r.t. 2.) THF, 18 h, r.t.

2: 100 percent / 98percent formic acid / Ambient temperature

3: 50 percent / hydroxylamine hydrochloride, pyridine / ethanol / 0.25 h / Ambient temperature

4: 46 percent / LiAlH / diethyl ether / 4 h / Heating

5: 74 percent / triethylamine / ethanol / 48 h / Heating

With pyridine; formic acid; hydroxylamine hydrochloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; triethylamine; In diethyl ether; ethanol;
DOI:10.1002/jhet.5570270655