(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

Base Information

Chemical Name:(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester
CAS No.:1350440-70-8
Molecular Formula:C₂₇H₃₁N₃O₈S₂
Molecular Weight:589.69
Hs Code.:

Synonyms:(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

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Chemical Property of (3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

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Technology Process of (3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

There total 3 articles about (3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350440-69-5
4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio-acetic acid methyl ester

: 179087-93-5
[4-[[2,4-dioxo-1,3-thiazolidine-5-yl]methyl]phenoxy]acetic acid

: 1350440-70-8
(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 27h;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350440-70-8
(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Cooling with ice

1.2: 2.33 h / 20 - 60 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 27 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350440-68-4
3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

: 1350440-70-8
(3-(N-t-butoxycarbonyl-N-methylamino)-4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]phenylthio)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 27 h / 20 °C

With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;