1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

Base Information

Chemical Name:1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid
CAS No.:1350440-72-0
Molecular Formula:C₂₁H₁₉N₃O₅S₂
Molecular Weight:457.531
Hs Code.:

Synonyms:1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

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Chemical Property of 1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

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Technology Process of 1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

There total 5 articles about 1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-yl-thioacetic acid methyl ester hydrochloride

: 1350440-72-0
1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 90 ℃; for 24h;

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350440-72-0
1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / Cooling with ice

1.2: 2.33 h / 20 - 60 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 27 h / 20 °C

4.1: hydrogenchloride / methanol; 1,4-dioxane / 27 h / 55 - 70 °C

5.1: acetic acid; hydrogenchloride / water / 24 h / 90 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1350440-68-4
3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

: 1350440-72-0
1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 27 h / 20 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 27 h / 55 - 70 °C

4: acetic acid; hydrogenchloride / water / 24 h / 90 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;