3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

Base Information

Chemical Name:3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester
CAS No.:1350440-68-4
Molecular Formula:C₁₅H₂₀N₂O₆S
Molecular Weight:356.4
Hs Code.:

Synonyms:3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

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Chemical Property of 3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

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Technology Process of 3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

There total 1 articles about 3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 2365-48-2
Methyl thioglycolate

: 1350440-68-4
3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

Guidance literature:: Methyl thioglycolate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.333333h; Cooling with ice;

N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 20 - 60 ℃; for 2.33h;

Reference yield:

: 1350440-68-4
3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

: 1350440-69-5
4-amino-3-(N-t-butoxycarbonyl-N-methylamino)phenylthio-acetic acid methyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1350440-68-4
3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenylthio-acetic acid methyl ester

: 1350440-72-0
1-methyl-2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-1H-benzimidazol-6-ylthio-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 27 h / 20 °C

3: hydrogenchloride / methanol; 1,4-dioxane / 27 h / 55 - 70 °C

4: acetic acid; hydrogenchloride / water / 24 h / 90 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;