1122-12-9

Basic information

• Product Name: DIBROMOMALEIC ANHYDRIDE
• Synonyms: DIBROMOMALEIC ANHYDRIDE;3,4-Dibromo-2,5-furandione;3,4-dibromofuran-2,5-dione;3,4-dibromofuran-2,5-quinone;2,5-Furandione, 3,4-dibroMo-
• CAS NO: 1122-12-9
• Molecular Formula: C₄Br₂O₃
• Molecular Weight: 255.85
• Mol File: 1122-12-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 118-119 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 252.1 °C at 760 mmHg
• Flash Point: 106.3 °C
• Appearance: /
• Density: 2.819 g/cm³
• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: 1.71
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: DIBROMOMALEIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIBROMOMALEIC ANHYDRIDE(1122-12-9)
• EPA Substance Registry System: DIBROMOMALEIC ANHYDRIDE(1122-12-9)

Safety Data

• Hazardous Substances Data: 1122-12-9(Hazardous Substances Data)

Usage

General Description

Dibromomaleic anhydride is a chemical compound with the molecular formula C4H2Br2O3. It is a white crystalline solid that is soluble in organic solvents such as acetone and methanol. It is primarily used to produce corrosion inhibitors, flame retardants, and specialty polymers. It is also used as a crosslinking agent in polymer chemistry and as a reagent in organic synthesis. Dibromomaleic anhydride is considered to be irritant to the skin, eyes, and respiratory system and should be handled with caution. Due to its potential environmental and health hazards, its use is regulated in many countries.

InChI:InChI=1/C4Br2O3/c5-1-2(6)4(8)9-3(1)7

Upstream product

• 608-37-7 dibromomaleic acid 
• 32460-09-6 2,3,4,5-tetrabromofuran 
• 21577-50-4 mucobromic acid 
• 7726-95-6 bromine 
• 543-20-4 succinoyl dichloride 
• 108-30-5 succinic acid anhydride 
• 108-31-6 maleic anhydride 
• 55052-06-7 dibromomaleic acid monoethyl ester 
• 5926-51-2 bromomaleic anhydride 

Downstream Products

• 15111-21-4 diiodomaleic anhydride 
• 1426960-57-7 1-(benzyloxy)-3,4-dibromo-1H-pyrrole-2,5-dione 
• 1353567-37-9 C₁₄H₁₀Br₃NO₄ 
• 1345041-61-3 3,4-bis(2-methyl-5-phenylthiophene-3-yl)furan-2,5-dione 
• 65833-16-1 3,4-dibromo-1-(4-nitrophenyl)-1H-pyrrole-2,5-dione 
• 1122-10-7 2,3-dibromomaleimide 
• 91026-00-5 N-benzyl-2,3-dibromo-maleimide 
• 65833-14-9 3,4-dibromo-2,5-dihydro-1-phenyl-1H-pyrrole-2,5-dione 
• 92751-35-4 3,4-dibromo-2,5-dihydro-1-(ethylphenyl)-1H-pyrrole-2,5-dione 

Relevant articles and documents

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones

Due to their exquisite cysteine-selectivity, excellent stability, and ability to functionally rebridge disulfide bonds, dibromopyridazinediones are emerging as an exciting new class of bioconjugation reagents, particularly in the field of antibody conjugation. Despite this, relatively little work has been performed on the optimisation of their synthesis and subsequent reaction with immunoglobulins. Herein we present a novel synthetic route towards functionalised dibromopyridazinediones, proceeding via an isolatable dibromopyridazinedione-NHS ester. Reaction of this activated intermediate with a variety of amines produces functional dibromopyridazinediones in good to excellent yields. The disulfide rebridging capacity of these reagents was optimised on the clinically relevant IgG1 trastuzumab, resulting in a general method which allows for the generation of site-selectively modified native trastuzumab with over 90% homogeneity (no disulfide scrambling) without the need for protein engineering or enzymatic conjugation.

Co-sensitization of N719 with polyphenylenes from the Bergman cyclization of maleimide-based enediynes for dye-sensitized solar cells

The co-sensitization of N719 with conjugated polyphenylenes for dye-sensitized solar cells (DSSCs) was demonstrated. The conjugated polyphenylenes (6-BC and 7-BC), which contain two triphenylamine (TPA) groups as electron donors and carboxylic acids as ad

PHOTOCHEMICAL TRANSFORMATION OF TETRABROMOFURAN BY OXYGEN INTO 2,3,4,4-TETRABROMOBUT-2-EN-4-OLIDE IN THE SOLID STATE

The solid-state photo-oxidation (1) -> (2) recorded by Torrey in 1897 has been verified and structure (2) confirmed; a possible mechanism for the transformation involving free radicals is suggested.In contrast, the bromination (5) -> (2) reported by Hill and Cornelison in 1894 could not be repeated despite many attempts.An ionic mechanism for the preparation (4) -> (6) is proposed; the semi-aldehyde (6) in solution exists solely in the lactol form (7).

PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF

This disclosure relates to compounds and compositions useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.

Maleimide-based acyclic enediyne for efficient DNA-cleavage and tumor cell suppression

A pH-sensitive acyclic enediyne (1) was synthesized for efficient DNA-cleavage and tumor cell suppression. Unlike other acyclic enediynes, this novel enediyne transforms into a highly reactive enediyne (2) in an acidic environment only, which undergoes Be