dimethyl isoquinolin-1-ylphosphonate

Base Information

• Chemical Name: dimethyl isoquinolin-1-ylphosphonate
• CAS No.: 78133-52-5
• Molecular Formula: C₁₁H₁₂NO₃P
• Molecular Weight: 237.195
• Mol file: 78133-52-5.mol

Synonyms:dimethyl isoquinolin-1-ylphosphonate

Chemical Property of dimethyl isoquinolin-1-ylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dimethyl isoquinolin-1-ylphosphonate

There total 1 articles about dimethyl isoquinolin-1-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isoquinoline N-oxide (1532-72-5) + phosphorous acid trimethyl ester (121-45-9) → trimethyl phosphite (512-56-1) + tetramethyl pyrophosphate (690-49-3) + dimethyl trichloromethylphosphonate (29238-81-1) + dimethyl phosphine oxide (7211-39-4) + dimethyl isoquinolin-1-ylphosphonate (78133-52-5)

Guidance literature:

With Bromotrichloromethane; In chloroform-d1; at 20 ℃; for 0.333333h;

DOI:10.1039/C7OB00402H

Reference yield: 29.0%

n-butyllithium (109-72-8,29786-93-4) + dimethyl isoquinolin-1-ylphosphonate (78133-52-5) → 1-butylisoquinoline (7661-38-3)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

DOI:10.1055/s-1999-3627

Reference yield: 28.0%

phenyllithium (591-51-5) + dimethyl isoquinolin-1-ylphosphonate (78133-52-5) → 1-phenylisoquinoline (3297-72-1)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

DOI:10.1055/s-1999-3627

upstream raw materials:

isoquinoline N-oxide

phosphorous acid trimethyl ester

Downstream raw materials:

1-butylisoquinoline

1-phenylisoquinoline