3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester

Base Information

• Chemical Name: 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester
• CAS No.: 312942-46-4
• Molecular Formula: C₉H₉ClN₂O₇S
• Molecular Weight: 324.699
• Mol file: 312942-46-4.mol

Synonyms:3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester

Chemical Property of 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester

There total 5 articles about 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorosalicylic acid (5106-98-9) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester (312942-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1: chlorosulfonic acid; SOCl₂ / 2 h / 0 °C

2: HNO₃; H₂SO₄ / 2 h / 65 - 70 °C

3: NH₃ / diethyl ether / 2 h / 0 °C

4: thionyl chloride / dioxane / 2 h / Heating

5: 2 h / Heating

With chlorosulfonic acid; thionyl chloride; sulfuric acid; ammonia; nitric acid; In 1,4-dioxane; diethyl ether;

DOI:10.1007/BF02524597

Reference yield:

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid (14665-31-7) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester (312942-46-4)

Guidance literature:

Multi-step reaction with 4 steps

1: HNO₃; H₂SO₄ / 2 h / 65 - 70 °C

2: NH₃ / diethyl ether / 2 h / 0 °C

3: thionyl chloride / dioxane / 2 h / Heating

4: 2 h / Heating

With thionyl chloride; sulfuric acid; ammonia; nitric acid; In 1,4-dioxane; diethyl ether;

DOI:10.1007/BF02524597

Reference yield:

3-nitro-4-chloro-5-chlorosulfonylsalicylic acid (328553-76-0) → 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester (312942-46-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / diethyl ether / 2 h / 0 °C

2: thionyl chloride / dioxane / 2 h / Heating

3: 2 h / Heating

With thionyl chloride; ammonia; In 1,4-dioxane; diethyl ether;

DOI:10.1007/BF02524597

upstream raw materials:

ethanol

3-nitro-4-chloro-5-sulfamoylsalicylic acid chloroanhydride

4-chlorosalicylic acid

4-chloro-5-chlorosulfonyl-2-hydroxybenzoic acid

Downstream raw materials:

3-amino-4-chloro-5-sulfamoylsalicylic acid ethyl ester