(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

Base Information

Chemical Name:(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one
CAS No.:248922-23-8
Molecular Formula:C₃₃H₄₁F₂N₃O₄
Molecular Weight:581.703
Hs Code.:

Synonyms:(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

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Chemical Property of (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

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Technology Process of (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

There total 3 articles about (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 248922-15-8
(S)-2-amino-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-pentan-1-one

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 144-55-8
sodium hydrogencarbonate

: 248922-23-8
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; ethyl acetate;

Reference yield:

: 27469-60-9
1-(4-fluorophenyl)methyl-piperazine

: 248922-23-8
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether; ethyl acetate; N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane

3: sodium tris(acetoxy)borohydride / dichloromethane; ethyl acetate

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 200937-21-9
N-tert-butoxycarbonyl-L-leucine monohydrate

: 248922-23-8
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-2-(3,4,5-trimethoxy-benzylamino)-pentan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether; ethyl acetate; N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane

3: sodium tris(acetoxy)borohydride / dichloromethane; ethyl acetate

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;