4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide
• CAS No.: 676591-83-6
• Molecular Formula: C₁₈H₂₁NO₂SSi
• Molecular Weight: 343.522
• Mol file: 676591-83-6.mol

Synonyms:4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide

Chemical Property of 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide

There total 6 articles about 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phenyl toluenesulfonamide (68-34-8) + trimethylsilylacetylene (1066-54-2) → 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide (676591-83-6)

Guidance literature:

phenyl toluenesulfonamide; With pyridine; oxygen; sodium carbonate; copper dichloride; In toluene; at 70 ℃; for 0.25h;

trimethylsilylacetylene; In toluene; at 70 ℃; for 8h;

DOI:10.1002/anie.201103563

Reference yield: 78.0%

chloro-trimethyl-silane (75-77-4) + N-(2,2-dichlorovinyl)-N-phenyl-4-methyl-benzenesulfonamide (312329-83-2) → 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide (676591-83-6)

Guidance literature:

N-(2,2-dichlorovinyl)-N-phenyl-4-methyl-benzenesulfonamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

chloro-trimethyl-silane; In tetrahydrofuran;

DOI:10.1055/s-2003-45010

Reference yield: 70.0%

chloro-trimethyl-silane (75-77-4) + N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide (312329-87-6) → 4-methyl-N-phenyl-N-[(trimethylsilyl)ethynyl]benzenesulfonamide (676591-83-6)

Guidance literature:

N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1055/s-2007-984529

upstream raw materials:

chloro-trimethyl-silane

N-(2,2-dichlorovinyl)-N-phenyl-4-methyl-benzenesulfonamide

N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide

phenyl toluenesulfonamide

Downstream raw materials:

2-oxo-N, 2-diphenyl-N-tosylacetamide

N-acetyl-N-phenyl-p-toluenesulfonamide

phenyl toluenesulfonamide

1-(toluene-4-sulfonyl)-1,3-dihydro-indol-2-one