Technology Process of (1S,4R)-N-(4-methoxyphenyl)-4-ethyl-4-phenyl-1,2-thiazetidin-3-one 1-oxide
There total 2 articles about (1S,4R)-N-(4-methoxyphenyl)-4-ethyl-4-phenyl-1,2-thiazetidin-3-one 1-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate;
In
dichloromethane;
at -78 ℃;
for 48h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Molecular sieve;
DOI:10.1002/anie.201102488
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride / Inert atmosphere
2: (S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate / dichloromethane / 48 h / -78 °C / Inert atmosphere; Molecular sieve
With
thionyl chloride; (S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate;
In
dichloromethane;
DOI:10.1002/anie.201102488
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1002/anie.201102488
