4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

Base Information

Chemical Name:4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one
CAS No.:58038-77-0
Molecular Formula:C₂₇H₂₃F₃N₂O
Molecular Weight:448.488
Hs Code.:

4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-<i>b</i>]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

Synonyms:4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

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Chemical Property of 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

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Technology Process of 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

There total 6 articles about 4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40132-01-2
1-(4-fluorophenyl)-4-bromo-1-butanone

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 58038-77-0
4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 65 ℃; for 4h;
DOI:10.1021/jm00180a011

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 58038-77-0
4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / ethanol / 1.75 h / Heating

2: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

3: 41 percent / KOH, water / ethanol / 23 h / Heating

4: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

With potassium hydroxide; water; sodium carbonate; potassium iodide; copper(I) bromide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 58038-77-0
4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-1-(4-fluoro-phenyl)-butan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / ethanol / 1.75 h / Heating

2: 78 percent / cuprous bromide, sodium carbonate / various solvent(s) / 8 h / 200 °C

3: 41 percent / KOH, water / ethanol / 23 h / Heating

4: NaCO₃, KI / dimethylformamide / 4 h / 65 °C

With potassium hydroxide; water; sodium carbonate; potassium iodide; copper(I) bromide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00180a011