C₂₉H₂₇N₅O₂

Base Information

• Chemical Name: C₂₉H₂₇N₅O₂
• CAS No.: 1246471-31-7
• Molecular Formula: C₂₉H₂₇N₅O₂
• Molecular Weight: 477.566
• Mol file: 1246471-31-7.mol

Synonyms:C₂₉H₂₇N₅O₂

Chemical Property of C₂₉H₂₇N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₇N₅O₂

There total 7 articles about C₂₉H₂₇N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C39H43N5O6 (1246471-28-2) → C29H27N5O2 (1246471-31-7)

Guidance literature:

With hydrogenchloride; In methanol; for 3h;

Reference yield:

5-amino-1H-indole (5192-03-0) → C29H27N5O2 (1246471-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dmap / acetonitrile; tetrahydrofuran / 0 - 25 °C

2.1: lithium diisopropyl amide; Triisopropyl borate / tetrahydrofuran / 2 h / 0 - 25 °C

2.2: pH 3

3.1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / Reflux; Inert atmosphere

4.1: hydrogenchloride / methanol / 3 h

With hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Triisopropyl borate; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; acetonitrile; 3.1: |Suzuki Coupling;

Reference yield:

α-amino-4-bromoacetophenone hydrochloride (5467-72-1) → C29H27N5O2 (1246471-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.83 h / Cooling with ice

2: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 160 °C / Sealed tube

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / Reflux; Inert atmosphere

4: hydrogenchloride / methanol / 3 h

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; acetonitrile; 3: |Suzuki Coupling;

upstream raw materials:

C₃₉H₄₃N₅O₆

5-amino-1H-indole

5-(tert-butoxycarbonylamino)-1-(tert-butoxycarbonyl)indole

(S)-benzyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate