(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

Base Information

Chemical Name:(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid
CAS No.:934285-30-0
Molecular Formula:C₃₄H₂₈ClNO₅
Molecular Weight:566.053
Hs Code.:

Synonyms:(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

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Technology Process of (2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

There total 5 articles about (2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 934285-29-7
methyl 4-{2-[2-[(1E)-3-(allyloxy)-3-oxoprop-1-en-1-yl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

: 934285-30-0
(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 4h;
DOI:10.1021/jm061131z

Reference yield: 97.0%

: 934285-30-0
(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

Guidance literature:

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 934285-30-0
(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2: 0.750 g / Ag₂CO₃; H₂O / acetone

3: 91 percent / tetrahydrofuran / 1 h

4: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

With morpholine; N-Bromosuccinimide; water; silver carbonate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; acetone;
DOI:10.1021/jm061131z