3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

Base Information

Chemical Name:3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid
CAS No.:540524-73-0
Molecular Formula:C₃₄H₃₀ClNO₅
Molecular Weight:568.069
Hs Code.:

Synonyms:3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

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Chemical Property of 3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

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Technology Process of 3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

There total 7 articles about 3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 540524-72-9
4-{2-[1-benzhydryl-2-(2-carboxy-vinyl)-5-chloro-1H-indol-3-yl]-ethoxy}-benzoic acid methyl ester

: 540524-73-0
3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

Guidance literature:: With hydrogen; 5 % platinum on carbon; In methanol; at 20 ℃; for 48h;

Reference yield: 79.0%

: 934285-30-0
(2E)-3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)acrylic acid

: 540524-73-0
3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

Guidance literature:: With hydrogen; platinum on activated charcoal; In methanol; for 24h; under 760.051 Torr;
DOI:10.1021/jm061131z

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 540524-73-0
3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2: 0.750 g / Ag₂CO₃; H₂O / acetone

3: 91 percent / tetrahydrofuran / 1 h

4: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

5: 79 percent / H₂ / Pt/C / methanol / 24 h / 760.05 Torr

With morpholine; N-Bromosuccinimide; water; hydrogen; silver carbonate; dibenzoyl peroxide; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; acetone;
DOI:10.1021/jm061131z