N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

Base Information

Chemical Name:N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide
CAS No.:1140917-99-2
Molecular Formula:C₂₀H₂₆ClN₃O₃
Molecular Weight:391.898
Hs Code.:

Synonyms:N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

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Chemical Property of N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

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Technology Process of N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

There total 2 articles about N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1140917-98-1
(R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride

: 29568-33-0
2-methoxy-5-chlorobenzoyl chloride

: 1140917-99-2
N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: (R)-((tetrahydrofuran-2-yl)methyl)hydrazine dihydrochloride

: 29568-33-0
2-methoxy-5-chlorobenzoyl chloride

: 1140917-99-2
N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

Guidance literature:: trimethylacetylacetonitrile; (R)-((tetrahydrofuran-2-yl)methyl)hydrazine dihydrochloride; With triethylamine; In ethanol; at 90 ℃; for 6h; Heating / reflux;

2-methoxy-5-chlorobenzoyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 55.0%

: 1140917-99-2
N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide

: 77-78-1
dimethyl sulfate

: 1140917-95-8
N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-chloro-2-methoxybenzamide

Guidance literature:: N-{3-tert-butyl-1-[(2R)-tetrahydrofuran-2-ylmethyl]-1H-pyrazol-5-yl}-5-chloro-2-methoxybenzamide; dimethyl sulfate; In toluene; at 130 ℃; for 1h; Microwave irradiation;

With triethylamine; In methanol;