diethyl 6-methylcyclohex-1-enyl phosphate

Base Information

• Chemical Name: diethyl 6-methylcyclohex-1-enyl phosphate
• CAS No.: 30908-59-9
• Molecular Formula: C₁₁H₂₁O₄P
• Molecular Weight: 248.259
• Mol file: 30908-59-9.mol

Synonyms:diethyl 6-methylcyclohex-1-enyl phosphate

Chemical Property of diethyl 6-methylcyclohex-1-enyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl 6-methylcyclohex-1-enyl phosphate

There total 3 articles about diethyl 6-methylcyclohex-1-enyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl chlorophosphate (814-49-3) + 2-Methylcyclohexanone (583-60-8) → diethyl 6-methylcyclohex-1-enyl phosphate (30908-59-9)

Guidance literature:

With n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1.) THF, hexane, -78 degC, 30 min., 2.) -78 degC to room temp., 1h;

DOI:10.1055/s-1981-29680

Reference yield:

1-tert-butyldimethylsilyloxy-6-methyl-1-cyclohexene (20152-34-5) → diethyl 6-methylcyclohex-1-enyl phosphate (30908-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluorormethanesulfonic acid / chloroform-d1 / 2 h / Molecular sieve; Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 3.17 h / -78 - 20 °C / Inert atmosphere

With trifluorormethanesulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; chloroform-d1; hexane;

DOI:10.1021/ol2012132

Reference yield:

→ diethyl 6-methylcyclohex-1-enyl phosphate (30908-59-9)

Guidance literature:

2-Methyl-6-bromocyclohexanon, TEP;

upstream raw materials:

diethyl chlorophosphate

2-Methylcyclohexanone

1-tert-butyldimethylsilyloxy-6-methyl-1-cyclohexene

Downstream raw materials:

1-<(diethoxyphosphinyl)oxy>-2-methyl-1-cyclohexene

2-butyl-2-methyl-cyclohexanone

Trimethyl-(6-methyl-cyclohex-1-enylmethyl)-silane