2-n-Butyl-2-methylcyclohexanone

Base Information

• Chemical Name: 2-n-Butyl-2-methylcyclohexanone
• CAS No.: 1197-78-0
• Molecular Formula: C11H20 O
• Molecular Weight: 168.279
• Mol file: 1197-78-0.mol

Synonyms:2-Butyl-2-methylcyclohexanone;2-Methyl-2-butylcyclohexanone

Chemical Property of 2-n-Butyl-2-methylcyclohexanone

Chemical Property:

• Boiling Point: 116 °C (22 mmHg)
• PSA: 17.07000
• LogP: 3.32600

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-n-Butyl-2-methylcyclohexanone

There total 12 articles about 2-n-Butyl-2-methylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-methyl-2-<1-(phenylthio)butyl>-1-cyclohexanone (72653-66-8) → 2-butyl-2-methyl-cyclohexanone (1197-78-0)

Guidance literature:

W-2 Raney nickel; In ethanol; acetone; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(01)86667-9

Reference yield: 61.0%

2-(but-3-ynyl)-2-methylcyclohexanone (17520-16-0) → 2-butyl-2-methyl-cyclohexanone (1197-78-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h;

DOI:10.1021/ja00390a008

Reference yield: 37.0%

1-iodo-butane (542-69-8) + 1-trimethylsilyloxy-2-methyl-1-cyclohexene (19980-35-9) → 2-butyl-2-methyl-cyclohexanone (1197-78-0)

Guidance literature:

With 4 A molecular sieve; trimethyl(benzyl)ammonium fluoride; In tetrahydrofuran; 1.) room temperature, overnight, 2.) 0 deg C, 10 min, 3.) 20 deg C, 1 h;

DOI:10.1021/ja00368a018

upstream raw materials:

2-Methylcyclohexanone

2,6-dibromo-2-methyl-cyclohexanone

Di-n-butyl-(2-n-butyl-cyclohexen-1-yloxy)boran

methyl iodide

Downstream raw materials:

(6-Butyl-6-methyl-cyclohex-1-enyloxy)-trimethyl-silane

2-Butyl-2-methyl-6-(toluene-4-sulfonyloxy)-hexanoic acid methyl ester

Refernces

• 1、 Liu, Hsing-Jang,Zhu, Jia-Liang,Shia, Kak-Shan. "Lithium naphthalenide induced reductive alkylation of α-cyano ketones. A general method for regiocontrol of α,α-dialkylation of ketones". . p. 4183 - 4186. Retrieved 2007/10/03.
• 2、 Paterson, Ian. "α-ALKYLATION AND α-ALKYLIDENATION OF CARBONYL COMPOUNDS BY O-SILYLATED ENOLATE PHENYLTHIOALKYLATION". . p. 4207 - 4220. Retrieved 2007/10/02.