2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Base Information

Chemical Name:2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol
CAS No.:23180-29-2
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

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Chemical Property of 2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

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Technology Process of 2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

There total 3 articles about 2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1275589-14-4
C₂₁H₂₃NO₅

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 23180-29-2
2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Guidance literature:: C₂₁H₂₃NO₅; With ammonia; lithium; In tetrahydrofuran; isopropyl alcohol; at -70 - -60 ℃; for 1.5h;

methanol; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1033384-69-8
C₂₀H₂₃NO₅

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 23180-29-2
2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / toluene / 1 h / 20 °C

2.1: triethylamine / N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ / acetonitrile / 16 h / 20 °C / Inert atmosphere

3.1: ammonia; lithium / isopropyl alcohol; tetrahydrofuran / 1.5 h / -70 - -60 °C

3.2: 2 h / 20 °C / Cooling with ice; Inert atmosphere

With ammonia; lithium; triethylamine; trichlorophosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; In tetrahydrofuran; isopropyl alcohol; toluene; acetonitrile; 1.1: Bischler-Napieralski Reaction / 3.1: Birch Reduction;

Reference yield:

: 23180-29-2
2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Guidance literature:: 1-(3-Methoxycarbonylhydroxy-4-methoxy-benzyl)-2-methoxycarbonyl-6-methoxy-1,2,3,4-tetrahydro-isochinolin, LiAlH4, sd. Ae., 24 Std.;

upstream raw materials:

C₂₀H₂₃NO₅

methanol

C₂₁H₂₃NO₅

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