2-Propenenitrile,3-(2-pyridinyl)-(9CI)

Base Information

• Chemical Name: 2-Propenenitrile,3-(2-pyridinyl)-(9CI)
• CAS No.: 100949-40-4
• Molecular Formula: C₈H₆N₂
• Molecular Weight: 130.149
• Mol file: 100949-40-4.mol

Synonyms:2-Pyridineacrylonitrile(6CI); 3-(2-Pyridinyl)acrylonitrile; b-(2-Pyridyl)acrylonitrile

Chemical Property of 2-Propenenitrile,3-(2-pyridinyl)-(9CI)

Chemical Property:

• Melting Point: 83.5 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 160 °C(Press: 9 Torr)
• PKA: 3.83±0.10(Predicted)
• PSA: 36.68000
• Density: 1.112±0.06 g/cm3(Predicted)
• LogP: 1.61838

Purity/Quality:

3-(Pyridin-2-yl)prop-2-enenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenenitrile,3-(2-pyridinyl)-(9CI)

There total 11 articles about 2-Propenenitrile,3-(2-pyridinyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 3-(2-pyridinyl)-2-propenenitrile (100949-40-4)

Guidance literature:

With oxygen; sodium hydroxide; at 50 ℃; for 15h;

Reference yield: 81.0%

pyridine-2-carbaldehyde (1121-60-4) + chloroacetonitrile (107-14-2) → 3-(2-pyridyl)-prop-2-enyl nitrile (39077-58-2,39077-59-3,100949-40-4)

Guidance literature:

With tri-n-butylarsine; iodine; magnesium; In tetrahydrofuran; at 80 ℃; for 3h;

DOI:10.1080/00397919608004795

Reference yield: 15.0%

pyridine-2-carbaldehyde (1121-60-4) → 3-(2-pyridinyl)-2-propenenitrile (100949-40-4)

Guidance literature:

diethyl cyanoethylphosphonate; With sodium hydride; In tetrahydrofuran; for 1h;

pyridine-2-carbaldehyde; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

upstream raw materials:

pyridine-2-carbaldehyde

chloroacetonitrile

(1,1-dimethylethoxy)diphenylsilylacetonitrile

acetonitrile

Downstream raw materials:

2-(2-Cyanoethyl)pyridine

3-(1-oxide-2-pyridyl)propionitrile

Refernces

• 1、 Pérez, Juana M.,Postolache, Roxana,Casti?eira Reis, Marta,Sinnema, Esther G.,Vargová, Denisa,De Vries, Folkert,Otten, Edwin,Ge, Luo,Harutyunyan, Syuzanna R.. "Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation". supporting information. p. 20071 - 20076. Retrieved 2021/12/03.
• 2、 -. "Method for synthesizing substituted acrylonitrile with one-pot process". Paragraph 0022; 0023; 0024; 0037; 0038; 0039; 0041. . Retrieved 2017/06/02.