2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid

Base Information

• Chemical Name: 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid
• CAS No.: 213541-12-9
• Molecular Formula: C₂₅H₁₇F₂NO₄
• Molecular Weight: 433.411

Synonyms:2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid

Chemical Property of 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid

Chemical Property:

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Technology Process of 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid

There total 2 articles about 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) → 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid (213541-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

With potassium hydroxide; aluminium trichloride; In 1,4-dioxane; ethanol; dichloromethane; water; 1: Friedel-Crafts reaction / 2: Pfitzinger reaction;

DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

2-fluorobiphenyl (321-60-8) → 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid (213541-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

With potassium hydroxide; aluminium trichloride; In 1,4-dioxane; ethanol; dichloromethane; water; 1: Friedel-Crafts reaction / 2: Pfitzinger reaction;

DOI:10.1016/S0968-0896(01)00238-3

Reference yield: 99.0%

methanol (67-56-1) + 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid (213541-12-9) → 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid (406219-68-9)

Guidance literature:

2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid; With thionyl chloride; In toluene; at 50 ℃; for 3h;

methanol; In toluene; at 0 ℃; for 3h;

DOI:10.1016/S0968-0896(01)00238-3

upstream raw materials:

methyl 4-(chlorocarbonyl)butyrate

2-fluorobiphenyl

Downstream raw materials:

methyl 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylate

2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

2-[4-(2-fluorophenyl)phenyl]-3-(2-methoxycarbonylethyl)-4-methyl-6-fluoroquinoline

2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-methyl-6-fluoroquinoline

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