2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

Base Information

Chemical Name:2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl
CAS No.:1254981-34-4
Molecular Formula:C₁₇H₁₆ClF₃N₂
Molecular Weight:340.776
Hs Code.:

Synonyms:2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

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Technology Process of 2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

There total 1 articles about 2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 771-99-3
4-phenylpiperidine

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1254981-34-4
2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

Guidance literature:: 4-phenylpiperidine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

2,4-dichloro-3-(trifluoromethyl)pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

Reference yield: 93.0%

: 1254981-34-4
2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

: 1254981-35-5
(4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; at 160 ℃; for 2.25h; Microwave irradiation;

Reference yield:

: 1254981-34-4
2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

: 1254978-10-3
3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / tetrahydrofuran / 0.75 h / 20 - 160 °C / Microwave irradiation

2.1: triethylamine / dichloromethane / 20 °C

2.2: 150 °C / Microwave irradiation

With hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm3010724