3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Base Information

• Chemical Name: 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
• CAS No.: 1254978-10-3
• Molecular Formula: C₂₀H₂₁F₃N₄
• Molecular Weight: 374.409

Synonyms:3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Chemical Property of 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine

There total 4 articles about 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine (1254981-35-5) + propionyl chloride (79-03-8) → 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine (1254978-10-3)

Guidance literature:

(4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine; propionyl chloride; With triethylamine; In dichloromethane; at 20 ℃;

With trichlorophosphate; at 150 ℃; Microwave irradiation;

DOI:10.1021/jm3010724

Reference yield:

2,4-dichloro-3-(trifluoromethyl)pyridine (1186194-98-8) → 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine (1254978-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 1 h / 20 °C

2.1: hydrazine hydrate / tetrahydrofuran / 0.75 h / 20 - 160 °C / Microwave irradiation

3.1: triethylamine / dichloromethane / 20 °C

3.2: 150 °C / Microwave irradiation

With sodium hydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm3010724

Reference yield:

2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl (1254981-34-4) → 3-ethyl-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine (1254978-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / tetrahydrofuran / 0.75 h / 20 - 160 °C / Microwave irradiation

2.1: triethylamine / dichloromethane / 20 °C

2.2: 150 °C / Microwave irradiation

With hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm3010724

upstream raw materials:

2,4-dichloro-3-(trifluoromethyl)pyridine

2'-chloro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl

(4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

propionyl chloride

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