1-(4-BROMO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE

Base Information

• Chemical Name: 1-(4-BROMO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• CAS No.: 100397-96-4
• Molecular Formula: C13H10 Br N O
• Molecular Weight: 276.132
• Hs Code.: 2933399090
• Mol file: 100397-96-4.mol

Synonyms:Acetophenone,4'-bromo-2-(4-pyridyl)- (6CI)

Chemical Property of 1-(4-BROMO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE

Chemical Property:

• PSA: 29.96000
• LogP: 3.26950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Bromophenyl)-2-(4-pyridinyl)-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BROMO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE

There total 5 articles about 1-(4-BROMO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

picoline (108-89-4) + 4-bromo-N-methoxy-N-methylbenzamide (192436-83-2) → 1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (100397-96-4)

Guidance literature:

picoline; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

4-bromo-N-methoxy-N-methylbenzamide; In tetrahydrofuran; at -65 ℃; for 1.25h; Inert atmosphere;

Reference yield: 72.4%

picoline (108-89-4) + 4-bromobenzenecarbonitrile (623-00-7) → 1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (100397-96-4)

Guidance literature:

picoline; 4-bromobenzenecarbonitrile; With n-butyllithium; In tetrahydrofuran; at -78 - 22 ℃; for 20.5h;

With water; hydrogen bromide;

Reference yield:

4-Bromobenzoic acid (586-76-5) → 1-(4-bromophenyl)-2-(pyridin-4-yl)ethanone (100397-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole; triethylamine / dichloromethane / 20 °C

2.1: lithium diisopropyl amide / -78 °C

2.2: -78 - 20 °C

With triethylamine; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In dichloromethane;

DOI:10.1039/c2md20239e

upstream raw materials:

1-(4-bromo-phenyl)-2-[1-(2,6-dichloro-benzyl)-1H-[4]pyridyliden]-ethanone

4-Bromobenzoic acid

picoline

4-bromo-N-methoxy-N-methylbenzamide

Downstream raw materials:

C₁₅H₁₃N₃S

C₁₅H₁₃N₃S

C₂₆H₂₂N₄OS

C₂₆H₂₂N₄OS

Refernces

• 1、 Li, Junfeng,Jin, Hongjun,Zhou, Haiying,Rothfuss, Justin,Tu, Zhude. "Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A". . p. 443 - 449. Retrieved 2013/06/04.