(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

Base Information

Chemical Name:(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol
CAS No.:124895-76-7
Molecular Formula:C₃₂H₄₈O₆Si
Molecular Weight:556.815
Hs Code.:

Synonyms:(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

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Chemical Property of (2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

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Technology Process of (2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

There total 10 articles about (2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 124871-67-6
ethyl (2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethyl-2-nonenoate

: 124895-76-7
(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 2h;
DOI:10.1248/cpb.37.1160

Reference yield:

: 17728-88-0
ethyl 3-(trimethylsilyl)propionate

: 124895-76-7
(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / LDA / tetrahydrofuran / -83 deg C, -20 deg C, 2 h

2: 90 percent / Et₃N / benzene / 0.33 h / 7 °C

3: 99 percent / NaOEt / tetrahydrofuran / 3.5 h / Ambient temperature

4: 78 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

With lithium aluminium tetrahydride; sodium ethanolate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1248/cpb.37.1160

Reference yield:

: 27150-99-8
1,1-dimethoxy-1-(4-methoxyphenyl)ethane

: 124895-76-7
(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: CSA / CH₂Cl₂ / 2 h / Ambient temperature

2: 1N KOH / methanol / 18 h / Ambient temperature

3: 94 percent / oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 0.5 h / -60 - -50 °C

4: 99 percent / LDA / tetrahydrofuran / -83 deg C, -20 deg C, 2 h

5: 90 percent / Et₃N / benzene / 0.33 h / 7 °C

6: 99 percent / NaOEt / tetrahydrofuran / 3.5 h / Ambient temperature

7: 78 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

With potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; sodium ethanolate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.37.1160