2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone

Base Information

• Chemical Name: 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone
• CAS No.: 1469293-96-6
• Molecular Formula: C₂₅H₂₃F₃N₆O
• Molecular Weight: 480.492

Synonyms:2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone

Chemical Property of 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone

There total 4 articles about 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-phenyl-1-piperazine (92-54-6) + ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (1469293-82-0) → 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone (1469293-96-6)

Guidance literature:

With potassium carbonate; at 100 ℃; for 12h;

DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

2-O-acetamido-3-cyano-4-trifluoromethyl-6-phenylpyridine → 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone (1469293-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / 6 h / 100 °C

2: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

3: potassium carbonate / 12 h / 100 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;

DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-44-2) → 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone (1469293-96-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium iodide; potassium carbonate / acetone / 6 h / Reflux

2: hydrazine hydrate / 6 h / 100 °C

3: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

4: potassium carbonate / 12 h / 100 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;

DOI:10.1016/j.bmcl.2013.08.089

upstream raw materials:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

4-phenyl-1-piperazine

ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1469293-96-6 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send