(5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone

Base Information

Chemical Name:(5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone
CAS No.:249617-46-7
Molecular Formula:C₂₃H₃₁NO₂Si
Molecular Weight:381.59
Hs Code.:
Mol file:249617-46-7.mol

Synonyms:(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

Suppliers and Price of (5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of (5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone

Chemical Property:

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone

There total 8 articles about (5S)-5-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-2-Pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 149561-81-9
(-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 22h;
DOI:10.1002/(sici)1099-0690(200001)2000:1<115::aid-ejoc115>3.0.co;2-j

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 149561-81-9
(-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

Guidance literature:: (-)-(S)-5-(Hydroxydiphenylmethyl)pyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -20 - 10 ℃; for 1h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 39.5h;
DOI:10.1039/a901581g

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 1.25 h / -78 - 0 °C

1.2: Cooling with ice

2.1: triethylamine / dichloromethane / 7 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tetasy.2011.04.001