6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine

Base Information

• Chemical Name: 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine
• CAS No.: 603994-28-1
• Molecular Formula: C₆₂H₇₄N₆O₆Si₂
• Molecular Weight: 1055.48

Synonyms:6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine

Chemical Property of 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine

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Technology Process of 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine

There total 1 articles about 6-benzyloxy-N⁸-biphenyl-4-yl-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromo-1,1'-biphenyl (92-66-0) + 6-benzyloxy-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine (603994-27-0) → 6-benzyloxy-N8-biphenyl-4-yl-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine (603994-28-1)

Guidance literature:

With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; for 2h; Further Variations:; Reagents; Product distribution;

DOI:10.1016/S0040-4039(03)01484-9

Reference yield:

6-benzyloxy-N8-biphenyl-4-yl-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine (603994-28-1) → 2-amino-8-(biphenyl-4-ylamino)-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

Guidance literature:

Multi-step reaction with 2 steps

1: ZnBr₂ / CH₂Cl₂; propan-2-ol

2: H₂ / Pd black / tetrahydrofuran / 0.5 h

With hydrogen; zinc dibromide; palladium; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1016/S0040-4039(03)01484-9

Reference yield:

6-benzyloxy-N8-biphenyl-4-yl-N2-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine (603994-28-1) → N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (84283-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: ZnBr₂ / CH₂Cl₂; propan-2-ol

2: H₂ / Pd black / tetrahydrofuran / 0.5 h

3: Et₃N(HF)3 / tetrahydrofuran / 20 °C

With hydrogen; triethylamine tris(hydrogen fluoride); zinc dibromide; palladium; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1016/S0040-4039(03)01484-9

upstream raw materials:

4-bromo-1,1'-biphenyl

6-benzyloxy-N²-[bis-(4-methoxy-phenyl)-phenyl-methyl]-9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-9H-purine-2,8-diamine

Downstream raw materials:

O⁶-benzyl-8N-(4-biphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxy-guanosine

N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl

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