4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester

Base Information

• Chemical Name: 4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester
• CAS No.: 192698-76-3
• Molecular Formula: C₄₃H₄₈O₁₄
• Molecular Weight: 788.846
• Mol file: 192698-76-3.mol

Synonyms:4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester

Chemical Property of 4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester

There total 1 articles about 4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + Trifluoro-methanesulfonic acid 4-methoxy-3-{2-methoxy-3-[2-(2-methoxy-ethoxymethoxy)-5-trifluoromethanesulfonyloxy-benzyl]-5-trifluoromethanesulfonyloxy-benzyl}-5-(2-methoxy-3-methyl-5-trifluoromethanesulfonyloxy-benzyl)-phenyl ester → 4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester (192698-76-3)

Guidance literature:

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine; In dimethyl sulfoxide; at 75 ℃; for 3h;

DOI:10.1021/jo970596h

Reference yield:

4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester (192698-76-3) → C39H40O12

Guidance literature:

With sulfuric acid; In methanol; at 60 ℃; for 2h;

DOI:10.1021/jo970596h

Reference yield:

4-[(2-methoxyethoxy)methoxy]-3-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester (192698-76-3) → C73H74O19

Guidance literature:

Multi-step reaction with 4 steps

1: conc. H₂SO₄ / methanol / 2 h / 60 °C

2: 84 percent / morpholine, I₂ / CH₂Cl₂ / 3 h / 10 deg C to rt

3: 95 percent / NaH, DMPU / tetrahydrofuran / -15 deg C to rt

4: 81 percent / (Ph₃P)4Pd

With morpholine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; iodine; sodium hydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jo970596h

upstream raw materials:

methanol

carbon monoxide

Downstream raw materials:

3-iodo-4-hydroxy-5-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester

3-iodo-4-methoxy-5-(2-methoxy-4-(methoxycarbonyl)-3-{2-methoxy-4-(methoxycarbonyl)-3-[3-(methoxycarbonyl)-5-methylbenzyl]benzyl}benzyl)benzoic acid methyl ester