11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

Base Information

Chemical Name:11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone
CAS No.:1259320-90-5
Molecular Formula:C₁₈H₁₀ClFN₂O₅
Molecular Weight:388.739
Hs Code.:

Synonyms:11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

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Chemical Property of 11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

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Technology Process of 11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

There total 4 articles about 11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 79-37-8
oxalyl dichloride

: 1259320-80-3
2-(4-fluorobenzylamino)benzamide

: 1259320-90-5
11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1515/znb-2010-0916

Reference yield: 81.0%

: 79-37-8
oxalyl dichloride

: 1259320-83-6
1-(4-fluorobenzyl)-1H-benzo[e][1,4]diazepine-2,3,5(4H)-trione

: 1259320-90-5
11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1515/znb-2010-0916

Reference yield:

: 40534-52-9
N-(4-fluorobenzyl)isatoic anhydride

: 1259320-90-5
11a-chloro-10-(4-fluorobenzyl)benzo[e]oxazolo[3,2-a]-[1,4]diazepine-2,3,5,11(10H,11aH)-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / tetrahydrofuran / Cooling with ice

2: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C

3: 1H-imidazole / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; ammonia; In tetrahydrofuran;
DOI:10.1515/znb-2010-0916