N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

Base Information

Chemical Name:N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide
CAS No.:134907-78-1
Molecular Formula:C₂₃H₂₃N₃O₅S₂
Molecular Weight:485.585
Hs Code.:

Synonyms:N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

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Chemical Property of N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

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Technology Process of N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

There total 8 articles about N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134907-72-5
(E)‐3‐(4‐(methylsulfonyl)phenyl)acryloyl chloride

: N-(2-pyridylmethyl)-4-(methylamino)benzenesulfonamide

: 134907-78-1
N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

Guidance literature:: In pyridine; dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 134907-72-5
(E)‐3‐(4‐(methylsulfonyl)phenyl)acryloyl chloride

: 134907-54-3
N-(2-pyridylmethyl)-4-(methylamino)benzenesulfonamide dihydrochloride

: 134907-78-1
N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

Guidance literature:: With pyridine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00111a048

Reference yield:

: 5398-77-6
para-methanesulfonylbenzaldehyde

: 134907-78-1
N-(2-pyridylmethyl)-4-{N-methyl-N-[(E)-3-(4-methylsulfonylphenyl)-2-propenoyl]amino}benzensulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium hydroxide; water monomer / ethanol / 1 h / 50 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4.1: dichloromethane; pyridine / 2 h / 0 - 20 °C

With oxalyl dichloride; water monomer; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane;