ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

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Chemical Name:ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate
CAS No.:1621254-62-3
Molecular Formula:C₃₅H₃₄F₇N₃O₅
Molecular Weight:709.661
Hs Code.:

ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

Synonyms:ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

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Chemical Property of ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

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Technology Process of ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

There total 6 articles about ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 874288-38-7
4-(ethoxycarbonyl)-3-fluorophenyl boronic acid

: 1621255-74-0
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(2-chloro-5-methoxypyrimidin-4-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 1621254-62-3
ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1152029-16-7
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol

: 1621254-62-3
ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / Microwave irradiation

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation

5: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 4: |Suzuki Coupling / 5: |Suzuki Coupling;

Reference yield:

: 1053265-66-9
2-bromo-5,5'-bis-methylcyclohex-1-enylcarbaldehyde

: 1621254-62-3
ethyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / Microwave irradiation

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 120 °C / Microwave irradiation

5: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium acetate; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 4: |Suzuki Coupling / 5: |Suzuki Coupling;