N-ME-PHE-OME HCL

Base Information

• Chemical Name: N-ME-PHE-OME HCL
• CAS No.: 19460-86-7
• Molecular Formula: C11H16ClNO2
• Molecular Weight: 229.707
• Mol file: 19460-86-7.mol

Synonyms:1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%;

Chemical Property of N-ME-PHE-OME HCL

Chemical Property:

• Boiling Point: 314.9 °C at 760 mmHg
• Flash Point: 124.7 °C
• PSA: 38.33000
• LogP: 2.18300
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

N-alpha-Methyl-L-phenylalanine methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Me-Phe-OMe HCl

Technology Process of N-ME-PHE-OME HCL

There total 4 articles about N-ME-PHE-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

(S)-methyl 2-((tert-butoxycarbonyl)(methyl)amino)-3-phenylpropanoate (37553-64-3) → (N-methyl)-L-phenylalanine methyl ester hydrochloride (19460-86-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tet.2012.06.056

Reference yield: 90.0%

methanol (67-56-1) + N-Methyl-L-phenylalanine (2566-30-5) → (N-methyl)-L-phenylalanine methyl ester hydrochloride (19460-86-7)

Guidance literature:

With hydrogenchloride; for 12h; Ambient temperature;

DOI:10.1021/jm00178a012

Reference yield: 64.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + methyl iodide (74-88-4) → (N-methyl)-L-phenylalanine methyl ester hydrochloride (19460-86-7)

Guidance literature:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With lithium hydroxide monohydrate; In N,N-dimethyl-formamide; at 25 ℃; for 1.08333h; Inert atmosphere; Molecular sieve;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 18h; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.8b03536

upstream raw materials:

methanol

N-Methyl-L-phenylalanine

N-tert-butoxycarbonyl-L-phenylalanine

(S)-methyl 2-((tert-butoxycarbonyl)(methyl)amino)-3-phenylpropanoate

Downstream raw materials:

N-tert-butyloxycarbonylalanylphenylalanine methyl ester

D-(N-tert-butoxycarbonylalanyl)-L-phenylalanine methyl ester

benzyloxycarbonyl-tauryl-(N-methyl)-L-phenylalanine methyl ester

Boc-N-MeLeu-N-MePhe-OMe