(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

Base Information

Chemical Name:(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone
CAS No.:1636166-39-6
Molecular Formula:C₂₃H₁₉ClF₄N₄O₃S
Molecular Weight:542.941
Hs Code.:

Synonyms:(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

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Chemical Property of (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

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Technology Process of (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

There total 6 articles about (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1636166-33-0
(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(piperazin-1-yl)methanone

: 1636166-39-6
(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; for 3h; Reflux;
DOI:10.5935/0103-5053.20140073

Reference yield:

: 1636166-31-8
6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid

: 1636166-39-6
(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / 1,2-dichloro-ethane / 3 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / Reflux

3: triethylamine / 1,2-dichloro-ethane / 3 h / Reflux

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In 1,2-dichloro-ethane;
DOI:10.5935/0103-5053.20140073

Reference yield:

: 1636166-32-9
tert-butyl 4-(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carbonyl)piperazine-1-carboxylate

: 1636166-39-6
(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 1,2-dichloro-ethane / 6 h / Reflux

2: triethylamine / 1,2-dichloro-ethane / 3 h / Reflux

With triethylamine; trifluoroacetic acid; In 1,2-dichloro-ethane;
DOI:10.5935/0103-5053.20140073