N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide
CAS No.:1237750-46-7
Molecular Formula:C₂₂H₂₂F₃N₅OS
Molecular Weight:461.511
Hs Code.:

Synonyms:N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

There total 7 articles about N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

: 185040-32-8
4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

: 1237750-46-7
N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide; 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde; With acetic acid; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 0 - 20 ℃; for 25h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01618

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 1237750-46-7
N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / 6 h / 20 °C / Inert atmosphere

4.1: acetic acid / methanol / 0.5 h / 0 °C / Inert atmosphere

4.2: 25 h / 0 - 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01618

Reference yield:

: 76360-82-2
4-methylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 1237750-46-7
N-(4-methyl-3-(((4-(methylamino)-2-(methylthio)pyrimidin-5-yl)methyl)amino)phenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 6 h / 20 °C / Inert atmosphere

3.1: acetic acid / methanol / 0.5 h / 0 °C / Inert atmosphere

3.2: 25 h / 0 - 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01618