2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

Base Information

Chemical Name:2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide
CAS No.:1068970-09-1
Molecular Formula:C₁₉H₁₄FN₅O
Molecular Weight:347.351
Hs Code.:

Synonyms:2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

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Chemical Property of 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

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Technology Process of 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

There total 6 articles about 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1068976-97-5
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid chloride

: 161264-46-6
1-H-pyrrolo<2,3-b>pyridin-1-amine

: 1068970-09-1
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

Guidance literature:: With potassium carbonate; In water; ethyl acetate; at 20 ℃;

Reference yield:

: 933989-07-2
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid

: 1068970-09-1
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 °C

2: potassium carbonate / water; ethyl acetate / 20 °C

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; water; ethyl acetate;

Reference yield:

: 134653-70-6,51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

: 1068970-09-1
2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid pyrrolo[2,3-b]pyridin-1-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium / 0.5 h / 20 °C

1.2: 1 h / Heating / reflux

2.1: methanol; sodium hydroxide; water / tetrahydrofuran / 0.75 h / Heating / reflux

2.2: pH 2 - 3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.33 h / 0 °C

4.1: potassium carbonate / water; ethyl acetate / 20 °C

With methanol; sodium hydroxide; oxalyl dichloride; ethanol; water; sodium; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;