(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

Base Information

Chemical Name:(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester
CAS No.:888973-03-3
Molecular Formula:C₂₃H₃₅ClN₂O₅
Molecular Weight:454.994
Hs Code.:

Synonyms:(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

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Chemical Property of (2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

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Technology Process of (2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

There total 3 articles about (2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 888972-27-8
(4-chloro-2-formylphenoxy)acetic acid 1,1-dimethylethyl ester

: 169447-70-5
(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 888973-03-3
(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: (4-chloro-2-formylphenoxy)acetic acid 1,1-dimethylethyl ester; (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester; With magnesium sulfate; In tetrahydrofuran; at 18 - 25 ℃; for 20h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 20h; Inert atmosphere;
DOI:10.1021/jm1014549

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 888973-03-3
(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: magnesium sulfate / tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere

2.2: 20 h / Inert atmosphere

With magnesium sulfate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549

Reference yield:

: 635-93-8
5-chlorosalicyclaldehyde

: 888973-03-3
(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-methyl-1-piperazine carboxylic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere

2.1: magnesium sulfate / tetrahydrofuran / 20 h / 18 - 25 °C / Inert atmosphere

2.2: 20 h / Inert atmosphere

With magnesium sulfate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm1014549