1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

Base Information

Chemical Name:1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene
CAS No.:869287-33-2
Molecular Formula:C₁₇H₁₅N₅O
Molecular Weight:305.339
Hs Code.:

Synonyms:1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

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Chemical Property of 1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

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Technology Process of 1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

There total 2 articles about 1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 14080-23-0
2-cyanopyrimidine

: 75632-83-6
3-methyl-5-[(trimethylsilyl)methyl]isoxazole

: 100-47-0
benzonitrile

: 869287-33-2
1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

Guidance literature:: 3-methyl-5-[(trimethylsilyl)methyl]isoxazole; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h; Inert atmosphere;

benzonitrile; In tetrahydrofuran; hexane; at -70 ℃; for 1h; Inert atmosphere;

2-cyanopyrimidine; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201100040

Reference yield:

: 300-87-8
3,5-dimethyl-1,2-oxazole

: 869287-33-2
1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrimidin-2-yl)-2-azabutadiene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

1.2: 2 h / -70 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

2.2: 1 h / -70 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1002/chem.201100040